Abstract: GH4099 and pure copper was brazed with Ti-Zr-Ni-Cu filler metal by vacuum brazing. In vacuum brazing process,effects of process parameters on tensile strength of joints were investigated. Microstructure of the brazed joint with Ti-Zr-Ni-Cu filler metal was studied by means of scanning electron microscopy（ SEM）,Energy Dispersive Spectroscopy（ EDS） and X-ray diffraction（ XRD）. The results show that the microstructure of brazed seam consists of intermetallic compounds such as（ Ag,Cu）,（ Ni,Ti） and（ Cu,Ni,Ti）. The highest tensile strength of the joint is 182 MPa at the brazing temperature of 930 ℃ and the holding time of 10 min.