Abstract: Objective According to the actual needs of main construction of national energy freight transport trunk line and transformation and upgrading of automatic/intelligent welding equipment, and years of experience in designing and manufacturing automatic welding equipment for plate-beam end wall, welding production mode of flexible manufacturing robot for railway freight car end wall was constructed, and flexible manufacturing production line for end wall with multi-information sensor interaction and multi-robot wisdom collaboration was developed. Methods Flexible control method based on point laser triangulation and robot system was applied. Results Man-machine interactive symbiosis of the whole space trajectory in multi-axis heavy-duty robot system welding was realized and technical problems of determining weld position and welding blind zone operation under end wall frame structure were solved. Conclusion The production application showed that the flexible end wall robot welding production line met welding process requirements of end walls, which greatly improved production efficiency and realized flexible manufacturing of multi-specification end walls.