Abstract: To address corrosion failure of titanium alloys in deep submerged marine service environment, femtosecond laser etching was used to prepare corrosion-resistant super-hydrophobic micro- and nano-structure on surface of titanium alloy. Mechanism of laser etching parameters on the surface etched structure and interaction effect law of surface microstructure, hydrophobic property and salt spray corrosion behavior were investigated. The results showed that surface microstructure etched by femtosecond laser could trap air between microstructures and form an air protective film between liquid and substrate material. The support of air film structure to liquid improved hydrophobic ability of titanium alloy surface, reduced contact time and contact area between corrosive liquid and substrate metal, and further improved corrosion resistance of titanium alloy.