Abstract: Objective In the casting process of single crystal hollow turbine blades, process holes should be left in the bottom of blades in advance, so that ceramic core could flow out of blades after chemical corrosion. After core removal was completed, in order to ensure performance of hollow blades, it was necessary to use throttle to seal process holes. In view of this, laser welding of aero engine blade raw material DD6 monocrystalline alloy and GH3536 deformed superalloy dissimilar material was studied, and connection of DD6 and GH3536 dissimilar material was expected to be realized by laser welding, so as to solve the sealing problem. Methods In this paper, weldability of DD6 and GH3536 was studied, microstructure and elemental transition of DD6/GH3536 laser welded joints were observed, and mechanical properties of laser welded DD6 and non-laser welded DD6 were tested respectively. Results The results showed that the bottom of weld on the side of DD6 base metal was mainly fine columnar grains, and the top was equiaxed grains. After laser welding, a remelting crystallization zone with different grain orientation appeared on the side of DD6, and γ' phase near the remelting crystallization zone was melted. The results of high temperature tensile and high temperature endurance test showed that tensile strength and yield strength of welded joints were similar to those of DD6 base metal, and durability of welded joints was slightly higher than that of DD6 base metal. All the fractures occurred at the laser welding site of DD6. Conclusion Through laser welding, DD6 and GH3536 could be connected, and the connection was in good metallurgical condition.