Abstract: With the development of manufacturing technology of flux cored wire, the flux cored wire in ship welding materials accounts for more than 90%. The flux cored wire used at present are seamed flux cored wire, the welding process has some advantages such as high efficiency, good performance, strong adaptability, but wire feeding is difficult in welding process and there are some disadvantages such as easy corrosion and easy wire surface moisture absorption, difficult storage and transportation and so on. For seamless flux cored wire for surface copper plating processing, Proof-moisture in holding process and wire feeding in welding process are better than that of seamed flux cored wire. The SRSF501 seamless flux cored wire for welding of deposited metal test and process performance were introduced in this paper, which will be applied to the 13 000 t heavy lift ship (HLCV). The result show that the SRSF501 seamless flux cored wire can meet the requirements of ship welding, and show the superiority of the application of seamless flux cored wire. The seamless flux cored wire will be of great significance on the development of medicine core wire.