Abstract: Objective Defects in high-temperature alloy castings are often repaired by means of repair welding. To further investigate the impact of multiple repair welding on the performance of the casting at the same location. Methods This paper dissects a certain K4169 superalloy casting, makes repair welding test pieces, simulates the actual situation of different repair welding times at the same position of the casting body, and studies the effect of multiple repair welding on the microstructure and mechanical properties of K4169 superalloy welded joints through X-ray flaw detection, metallographic structure analysis, room temperature tensile test, high temperature endurance test, hardness test and cold and hot fatigue test. Results The results show that the visual surface quality of the repair welding area is good and there are no defects inside the repair welding area after multiple repair welding by TIG welding. The compactness of the weld structure at the repair welding position are good. The yield strength and tensile strength at room temperature do not decrease or increase significantly, but the average elongation after fracture, cross-sectional shrinkage rate and high temperature stress rupture property decreased gradually. The hardness of the weld position of the sample slightly increased and the cold and hot fatigue test results of the sample are qualified after multiple repair welding. There is no visible crack in the long-term service under the alternating temperature. Conclusion The defects in high-temperature alloy castings can be repaired by multiple repair welding methods, providing a reference for further optimizing the welding process and formulating defect repair processes in the future.